Endocrine Abstracts

Insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) have important metabolic roles in the human body. IGFBP-3 (40 and 45 kD glycoforms) is the most abundant in serum, whereas IGFBP-2 (34 kD) and IGFBP-1 (29 kD) are present at lower concentrations.Most inflammatory diseases of the gastrointestinal tract are characterised by a cytokine- mediated inflammatory reaction, malnutrition and catabolism. The aim of this work was to detect possib...

Insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) have important metabolic roles in the human body. IGFBP-3 (40 and 45 kD glycoforms) is the most abundant in serum, whereas IGFBP-2 (34 kD) and IGFBP-1 (29 kD) are present at lower concentrations.Most inflammatory diseases of the gastrointestinal tract are characterised by a cytokine- mediated inflammatory reaction, malnutrition and catabolism. The aim of this work was to detect possib...

Neuroendocrine tumours, although considered a rare neoplasia, have been increasing in incidence in developed countries over the last few decades. Previous research has identified several genetic components1. Despite this there is a gap in our knowledge of the causal mechanisms underlying the development of these tumours, with a low background mutation rate and lack of putative variants suggesting that other mechanisms are responsible. Recent work in Pancreatic Neuro...